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Raquel T. Lima

Researcher at University of Porto

Publications -  71
Citations -  7471

Raquel T. Lima is an academic researcher from University of Porto. The author has contributed to research in topics: Cell culture & Cell cycle. The author has an hindex of 22, co-authored 68 publications receiving 6754 citations. Previous affiliations of Raquel T. Lima include Institute of Molecular Pathology and Immunology of the University of Porto.

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Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
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MicroRNA regulation of core apoptosis pathways in cancer

Raquel T. Lima, +6 more
- 01 Jan 2011 - 
TL;DR: The current knowledge in this area is reviewed, including evidence of miRNA involvement in cancer drug resistance, and many pro-apoptotic miRNAs target anti-APoptotic mRNAs or their positive regulators.
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Specific downregulation of bcl-2 and xIAP by RNAi enhances the effects of chemotherapeutic agents in MCF-7 human breast cancer cells.

Raquel T. Lima, +7 more
- 01 May 2004 - 
TL;DR: Downregulation of bcl-2 or xIAP by RNAi enhances the effects of etoposide and doxorubicin and reduces the number of viable cells, when compared to either of the treatments alone.
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Anti-hepatocellular carcinoma activity using human HepG2 cells and hepatotoxicity of 6-substituted methyl 3-aminothieno[3,2-b]pyridine-2-carboxylate derivatives: in vitro evaluation, cell cycle analysis and QSAR studies.

Rui M.V. Abreu, +8 more
- 01 Dec 2011 - 
TL;DR: The methyl 3-amino-6-[(3-aminophenyl)ethynyl]thieno[3,2-b]pyridine-2-carboxylate (2f) is the most potent compound presenting GI(50) values on HepG2 cells of 1.2 μM compared to 2.9 μM of the positive control ellipticine, with no observed hepatotoxicity.
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Intercellular Transfer of Cancer Drug Resistance Traits by Extracellular Vesicles

Diana Sousa, +5 more
- 01 Oct 2015 - 
TL;DR: Extracellular vesicles (EVs) are nanosized particles enclosed by a phospholipid bilayer that have been described as important mediators of intercellular communication as discussed by the authors.