David Colecchia

TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: It is shown that NCOA4 deficiency in a knockout mouse model causes iron accumulation in the liver and spleen, increased levels of transferrin saturation, serum ferritin, and liver hepcidin, etc, and decreased levels of duodenal ferroportin.

TL;DR: It is demonstrated that MAPK15 is indeed localized to autophagic compartments and increased, in a kinase-dependent fashion, ATG8-like proteins lipidation, autophagosome formation and SQSTM1 degradation, while decreasing LC3B inhibitory phosphorylation.

TL;DR: Gint4.T-conjugated PNPs able of high uptake into U87MG glioblastoma cells and with astonishing EC50 value (38 pM) when loaded with a PI3K-mTOR inhibitor are synthesized.