Flavia Radogna

TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: The interesting timing of pro- and anti-inflammatory effects, such as those affecting lipoxygenase activity, suggests that melatonin might promote early phases of inflammation on one hand and contribute to its attenuation on the other hand, in order to avoid complications of chronic inflammation.

TL;DR: The effects of pharmacologically active compounds as modulators of different types of cancer cell death depending on the cellular context are summarized to highlight the potential role of these compounds for context-specific anticancer therapy.

TL;DR: It is shown that melatonin interferes with the intrinsic pathway of apoptosis at the mitochondrial level, providing a mechanism that may explain how melatonin through interaction with the MT1/MT2 receptors, elicits a pathway that interfered with the Bcl‐2 family, thus modulating the cell life/death balance.

TL;DR: The contribution of adaptive immunity to the long‐term clinical benefits of anticancer treatments and the properties of immune memory that can protect cancer patients against relapse are highlighted.