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Sam Gandy

Researcher at Icahn School of Medicine at Mount Sinai

Publications -  326
Citations -  30797

Sam Gandy is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Amyloid precursor protein & Alzheimer's disease. The author has an hindex of 76, co-authored 304 publications receiving 27731 citations. Previous affiliations of Sam Gandy include Main Line Health & Imperial College London.

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Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
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Familial Alzheimer's Disease–Linked Presenilin 1 Variants Elevate Aβ1–42/1–40 Ratio In Vitro and In Vivo

David R. Borchelt, +21 more
- 01 Nov 1996 - 
TL;DR: These studies provide compelling support for the view that one mechanism by which these mutant PS1 cause AD is by increasing the extracellular concentration of Abeta peptides terminating at 42(43), species that foster Abeta deposition.
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Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

Gopal Thinakaran, +16 more
- 01 Jul 1996 - 
TL;DR: It is concluded that PS1 is subject to endoproteolytic processing in vivo, and in brains of transgenic mice expressing human PS1, approximately 17 kDa and approximately 27 kDa PS1 derivatives accumulate to saturable levels, and at approximately 1:1 stoichiometry, independent of transgene-derived mRNA.
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Brain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums

Steven E. Arnold, +11 more
- 29 Jan 2018 - 
TL;DR: Key observations and experimental data on insulin signalling in the brain are reviewed and the concept of 'brain insulin resistance' is defined and the growing, although still inconsistent, literature concerning cognitive impairment and neuropathological abnormalities in T2DM, obesity and insulin resistance is reviewed.
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Apolipoprotein E epsilon4 associated with chronic traumatic brain injury in boxing

Barry D. Jordan, +5 more
- 09 Jul 1997 - 
TL;DR: Preliminary findings suggest that possession of an APOE epsilon4 allele may be associated with increased severity of chronic neurologic deficits in high-exposure boxers.