Andreas L. Serra

TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: In adults with ADPKD and early chronic kidney disease, 18 months of treatment with sirolimus did not halt polycystic kidney growth and the glomerular filtration rate did not differ significantly between the two groups; however, the urinary albumin excretion rate was higher in the siro Limus group.

TL;DR: Switching from calcineurin inhibitors to sirolimus had an antitumoral effect among kidney-transplant recipients with previous squamous-cell carcinoma, and these observations may have implications concerning immunosuppressive treatment of patients with cutaneous Squamous- cell carcinomas.

TL;DR: It is concluded that oral sirolimus markedly delays the loss of renal function and retards cyst development in Han:SPRD rats with ADPKD, and suggests that activation of the S6K signalling pathway plays an important role in the pathogenesis of PKD.

TL;DR: This study showed sustained regression of renal angiomyolipomas in patients with tuberous sclerosis or sporadic LAM receiving 2 years of sirolimus treatment, suggesting possible effects on pulmonary function and neurocognition require further investigation.