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Alexander Greenhough

Researcher at University of Bristol

Publications -  43
Citations -  7986

Alexander Greenhough is an academic researcher from University of Bristol. The author has contributed to research in topics: Wnt signaling pathway & Colorectal cancer. The author has an hindex of 22, co-authored 42 publications receiving 7161 citations. Previous affiliations of Alexander Greenhough include University of Sussex & University of the West of England.

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Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
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The COX-2/PGE2 pathway: key roles in the hallmarks of cancer and adaptation to the tumour microenvironment.

Alexander Greenhough, +6 more
- 01 Mar 2009 - 
TL;DR: A model for the cellular adaptation to the hypoxic tumour microenvironment that encompasses the interplay between COX-2, hypoxia-inducible factor 1 and dynamic switches in beta-catenin function that fine-tune signalling networks to meet the ever-changing demands of a tumour is proposed.
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Autolysosomal β-catenin degradation regulates Wnt-autophagy-p62 crosstalk.

Katy J. Petherick, +10 more
- 03 Jul 2013 - 
TL;DR: Findings reveal a regulatory feedback mechanism that place β‐catenin at a key cellular integration point coordinating proliferation with autophagy, with implications for targeting these pathways for cancer therapy.
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Live imaging of wound angiogenesis reveals macrophage orchestrated vessel sprouting and regression

David B Gurevich, +12 more
- 02 Jul 2018 - 
TL;DR: The cellular interactions between innate immune cells and endothelial cells at wounds that drive neoangiogenic sprouting are investigated in real time and in vivo in mouse and zebrafish wounds to indicate that macrophages are drawn to wound blood vessels soon after injury and are intimately associated throughout the repair process.
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The cannabinoid delta(9)-tetrahydrocannabinol inhibits RAS-MAPK and PI3K-AKT survival signalling and induces BAD-mediated apoptosis in colorectal cancer cells.

Alexander Greenhough, +3 more
- 15 Nov 2007 - 
TL;DR: It is shown for the first time that CB1 and CB2 cannabinoid receptors are expressed in human colorectal adenoma and carcinoma cells, and it is suggested an important role for CB1 receptors and BAD in the regulation of apoptosis in coloreCTal cancer cells.