Terry H. Landowski

TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: Findings provide evidence that constitutively activated Stat3 signaling contributes to the pathogenesis of multiple myeloma by preventing apoptosis.

TL;DR: Data show that both cell–cell adhesion of BMSCs with myeloma cells and soluble factors induced by this cell– cell interaction are involved in the protection of myelomas cells from mitoxantrone-induced apoptosis; however, the mechanisms contributing to the drug resistance are different.

TL;DR: It is proposed that Fas antigen mutations may contribute to the pathogenesis and progression of the neoplastic disease, multiple myeloma in some patients.

TL;DR: Analysis of oligonucleotide microarray analysis of the 8226 multiple myeloma cell line showed a predominant induction of gene products associated with the endoplasmic reticulum secretory pathway following short-term, high-dose exposure to bortezomib, supporting the hypothesis that intracellular Ca2+ disregulation is a critical determinant of bortzomib cytotoxicity.