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Pothana Saikumar

Researcher at University of Texas Health Science Center at San Antonio

Publications -  60
Citations -  9805

Pothana Saikumar is an academic researcher from University of Texas Health Science Center at San Antonio. The author has contributed to research in topics: Apoptosis & Programmed cell death. The author has an hindex of 31, co-authored 60 publications receiving 9093 citations. Previous affiliations of Pothana Saikumar include National Institutes of Health & Wistar Institute.

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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
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Acute kidney injury: a springboard for progression in chronic kidney disease

Manjeri A. Venkatachalam, +5 more
- 01 May 2010 - 
TL;DR: Considerations based on published and emerging data suggest that a pathology that develops in regenerating tubules after AKI characterized by failure of differentiation and persistently high signaling activity is the proximate cause that drives downstream events in the interstitium: inflammation, capillary rarefaction, and fibroblast proliferation.
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Apoptosis: definition, mechanisms, and relevance to disease

Pothana Saikumar, +5 more
- 01 Nov 1999 - 
TL;DR: Although apoptosis was described as a distinct entity nearly 3 decades ago, significant advances in the understanding of fundamental mechanisms that regulate this mode of cell death were made only recently.
Journal ArticleDOI

Bcl-2 prevents Bax oligomerization in the mitochondrial outer membrane.

Valery Mikhailov, +5 more
- 25 May 2001 - 
TL;DR: The data suggest that the in vivo actions of Bax are at least in part dependent on the formation of homo-oligomers without requiring associations with other molecules and that Bcl-2 cytoprotection involves mechanisms that prevent Bax oligomerization.
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Role of hypoxia-induced Bax translocation and cytochrome c release in reoxygenation injury

Pothana Saikumar, +6 more
- 31 Dec 1998 - 
TL;DR: By preserving mitochondrial integrity, BCL-2 prevents both forms of cell death and ensures cell viability in cultured kidney cells.