Eun-Kyoung Choi

TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: Calsenilin interacts with both PS1 and PS2 in cultured cells, and can regulate the levels of a proteolytic product of PS2, which may mediate the effects of wild-type and mutant presenilins on apoptosis and on Aß formation.

TL;DR: It is suggested that mitochondrial dysfunction caused by oxidative stress gives rise to neurodegeneration in prion disease.

TL;DR: The results suggest that prion accumulation in astrocytes might activate NF-kappaB through the increase of ROS generation, and thus alterations in NF- kappaB-directed gene expression may contribute to both the neurodegeneration and proinflammatory responses which occur in scrapie.

TL;DR: The results strongly suggest that PrP(C) may play a central role as an effective anti-apoptotic protein through caspase-dependent apoptotic pathways in mitochondria, supporting the concept that disruption of PrP (C) and consequent reduction of anti-APoptotic capacity ofPrP( C) may be one of the pathogenic mechanisms of prion diseases.