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Pablo Wappner

Researcher at Fundación Instituto Leloir

Publications -  48
Citations -  7318

Pablo Wappner is an academic researcher from Fundación Instituto Leloir. The author has contributed to research in topics: Hypoxia-inducible factors & Transcription factor. The author has an hindex of 23, co-authored 46 publications receiving 6696 citations. Previous affiliations of Pablo Wappner include National Scientific and Technical Research Council & Pontifical Catholic University of Chile.

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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
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Control of the Hypoxic Response in Drosophila melanogaster by the Basic Helix-Loop-Helix PAS Protein Similar

Sofía Lavista-Llanos, +8 more
- 01 Oct 2002 - 
TL;DR: Tight conservation of the HIF/prolyl hydroxylase system in Drosophila provides a new focus for understanding oxygen homeostasis in intact multicellular organisms.
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Sensing and responding to hypoxia via HIF in model invertebrates.

Thomas A. Gorr, +2 more
- 01 Apr 2006 - 
TL;DR: A similar life-preserving role for HIF-signaling in hypoxic, but not anoxic, environments had previously been established for another stress-tolerant invertebrate model, the nematode Caenorhabditis elegans.
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The PAS domain confers target gene specificity of Drosophila bHLH/PAS proteins.

Elazar Zelzer, +2 more
- 15 Aug 1997 - 
TL;DR: It is postulate that the capacity of bHLH/PAS heterodimers to associate, through the PAS domain, with additional distinct proteins that bind target-gene DNA, is essential to confer specificity.
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Cell autonomy of HIF effects in Drosophila: tracheal cells sense hypoxia and induce terminal branch sprouting.

Lazaro Centanin, +5 more
- 15 Apr 2008 - 
TL;DR: Drosophila tracheal terminal branches are plastic and have the capacity to sprout out projections toward oxygen-starved areas, in a process analogous to mammalian angiogenesis, and it is shown that extra sprouting depends on the Hypoxia-Inducible Factor (HIF)-alpha homolog Sima and on the HIF-prolyl hydroxylase Fatiga that operates as an oxygen sensor.