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Leonor Miller-Fleming

Researcher at University of Cambridge

Publications -  25
Citations -  6781

Leonor Miller-Fleming is an academic researcher from University of Cambridge. The author has contributed to research in topics: Autophagy & Huntingtin. The author has an hindex of 17, co-authored 23 publications receiving 6082 citations. Previous affiliations of Leonor Miller-Fleming include University of Leicester & Instituto de Biologia Molecular e Celular.

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Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
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Remaining Mysteries of Molecular Biology: The Role of Polyamines in the Cell.

Leonor Miller-Fleming, +4 more
- 23 Oct 2015 - 
TL;DR: The polyamines (PAs) spermidine, spermine, putrescine and cadaverine are an essential class of metabolites found throughout all kingdoms of life and their various intracellular functions are discussed.
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The NAD‐dependent deacetylase sirtuin 2 is a suppressor of microglial activation and brain inflammation

Teresa F. Pais, +10 more
- 02 Oct 2013 - 
TL;DR: This work identifies sirtuin 2 (SIRT2), an abundant deacetylase in the brain, as a major inhibitor of microglia‐mediated inflammation and neurotoxicity, and uncovers a novel role for SIRT2 opening new perspectives for therapeutic intervention in neuroinflammatory disorders.
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DJ-1 interactions with α -synuclein attenuate aggregation and cellular toxicity in models of Parkinson’s disease

L Zondler, +10 more
- 24 Jul 2014 - 
TL;DR: Data suggest that direct interactions between DJ-1 and aSyn constitute the basis for a neuroprotective mechanism and that familial mutations inDJ-1 may contribute to PD by disrupting these interactions.
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Microglia and inflammation: conspiracy, controversy or control?

Adelaide Fernandes, +3 more
- 10 Jul 2014 - 
TL;DR: Recent work presented in this review support that the understanding of microglial responses can pave the way to design new therapies for inflammatory diseases of the CNS and to highlight the molecular pathways that can counteract the detrimental role ofmicroglia in several neurologic diseases.