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Timothy J. Lyons

Researcher at Medical University of South Carolina

Publications -  150
Citations -  16619

Timothy J. Lyons is an academic researcher from Medical University of South Carolina. The author has contributed to research in topics: Diabetes mellitus & Glycation. The author has an hindex of 50, co-authored 148 publications receiving 14972 citations. Previous affiliations of Timothy J. Lyons include Hamm AG & University of Oklahoma Health Sciences Center.

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Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
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Effect of collagen turnover on the accumulation of advanced glycation end products.

Nicole Verzijl, +9 more
- 15 Dec 2000 - 
TL;DR: First experimental evidence that protein turnover is a major determinant in AGE accumulation in different collagen types is provided, thereby providing the first reasonable estimates of the half-lives of these collagens.
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The advanced glycation end product, Nepsilon-(carboxymethyl)lysine, is a product of both lipid peroxidation and glycoxidation reactions.

Min-Xin Fu, +5 more
- 26 Apr 1996 - 
TL;DR: The results suggest that lipid peroxidation, as well as glycoxidation, may be an important source of CML in tissue proteins in vivo and that CML may be a general marker of oxidative stress and long term damage to protein in aging, atherosclerosis, and diabetes.
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The progress in understanding and treatment of diabetic retinopathy

Alan W. Stitt, +10 more
- 01 Mar 2016 - 
TL;DR: It is emphasised that although there have been significant advances, there is still a pressing need for a better understanding basic mechanisms enable development of reliable and robust means to identify patients at highest risk, and to intervene effectively before vision loss occurs.
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Maillard reaction products and their relation to complications in insulin-dependent diabetes mellitus

David R. McCance, +6 more
- 01 Jun 1993 - 
TL;DR: The data show that FL and Maillard products in skin correlate with functional abnormalities in other tissues and suggest that protein glycation and oxidation (glycoxidation) may be implicated in the development of diabetic retinopathy and early nephropathy.