John J. McMahon

TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: The mTOR pathway was examined in rats that had already developed chronic spontaneous seizures in a pilocarpine model and it was found that mTOR is aberrantly activated in brain tissues from rats with chronic seizures.

TL;DR: It is demonstrated that prolonged mitosis of radial glial progenitors directly alters neuronal fate specification and progeny viability and is defined as a new paradigm to understand how mitosis perturbations underlie brain size disorders such as microcephaly.

TL;DR: Autophagy is suppressed in brain tissues of forebrain-specific conditional TSC1 and phosphatase and tensin homlog knock-out mice and impaired autophagy contributes to epileptogenesis, which may be of interest as a potential therapeutic target for epilepsy treatment and/or prevention.

TL;DR: It is revealed that, in the developing mouse neocortex, ventricular zone progenitors become more hyperpolarized as they generate successive subtypes of neurons.