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Toshiro Okazaki

Researcher at Kanazawa Medical University

Publications -  85
Citations -  7218

Toshiro Okazaki is an academic researcher from Kanazawa Medical University. The author has contributed to research in topics: Ceramide & Sphingomyelin synthase. The author has an hindex of 25, co-authored 81 publications receiving 6531 citations. Previous affiliations of Toshiro Okazaki include Ishikawa Prefectural University & Tottori University.

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Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
Journal Article

Possible Role of Ceramide as an Indicator of Chemoresistance: Decrease of the Ceramide Content via Activation of Glucosylceramide Synthase and Sphingomyelin Synthase in Chemoresistant Leukemia

Mitsuru Itoh, +9 more
- 01 Jan 2003 - 
TL;DR: It is suggested that a decrease of the ceramide level via activation of GCS and SMS is associated with the chemoresistant condition in leukemia, probably in relation to Bcl-2 but not to MDR-1 expression.
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Mitochondrial Dysfunction and Increased Reactive Oxygen Species Impair Insulin Secretion in Sphingomyelin Synthase 1-null Mice

Masato Yano, +18 more
- 04 Feb 2011 - 
TL;DR: The data suggest that SMS1 is important for controlling ROS generation, and that SMS 1 is required for normal mitochondrial function and insulin secretion in pancreatic β-cells.
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Regulation of autophagy and its associated cell death by "sphingolipid rheostat": reciprocal role of ceramide and sphingosine 1-phosphate in the mammalian target of rapamycin pathway.

Makoto Taniguchi, +15 more
- 16 Nov 2012 - 
TL;DR: It is indicated that sphingolipid rheostat in ceramide-CAPPs and S1P-S1P3 signaling modulates autophagy and its associated cell death through regulation of the mTOR pathway.
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Japanese Variant of Multicentric Castleman's Disease Associated With Serositis and Thrombocytopenia — A Report of Two Cases: Is TAFRO Syndrome (Castleman- Kojima Disease) a Distinct Clinicopathological Entity?

Yasufumi Masaki, +14 more
- 01 Jan 2013 - 
TL;DR: Cases of TAFRO syndrome (Castleman-Kojima disease) are still rare and it is necessary to conduct multicenter clinical surveys including similar cases to reach a consensus regarding diagnostic criteria, therapeutic strategy, and pathophysiological etiology for this syndrome.