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Hugo Seca

Researcher at University of Porto

Publications -  20
Citations -  5884

Hugo Seca is an academic researcher from University of Porto. The author has contributed to research in topics: Programmed cell death & Apoptosis. The author has an hindex of 15, co-authored 20 publications receiving 5336 citations. Previous affiliations of Hugo Seca include Institute of Molecular Pathology and Immunology of the University of Porto.

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Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
Journal ArticleDOI

Multiple Myeloma: Available Therapies and Causes of Drug Resistance.

Vanessa Pinto, +10 more
- 10 Feb 2020 - 
TL;DR: This review focuses on the main drugs used in MM treatment and on causes of drug resistance, including cytogenetic, genetic and epigenetic alterations, abnormal drug transport and metabolism, dysregulation of apoptosis, autophagy activation and other intracellular signaling pathways, the presence of cancer stem cells, and the tumor microenvironment.
Journal ArticleDOI

Targeting miR-21 Induces Autophagy and Chemosensitivity of Leukemia Cells

Hugo Seca, +5 more
- 31 Aug 2013 - 
TL;DR: It was observed that miR-21 downregulation decreased cellular viability and proliferation, although no changes to the normal cell cycle profile were observed, and serum starvation (an autophagy inducer) increased sensitivity to these drugs, confirming that autophagic vacuoles sensitized these cells to the effect of these drugs.
Journal Article

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2459 more
- 01 Jan 2016 - 
Journal ArticleDOI

The network of P-glycoprotein and microRNAs interactions

Vanessa Lopes-Rodrigues, +10 more
- 15 Jul 2014 - 
TL;DR: This current issue reviews this current issue together with recent evidence of this network of interactions between P‐gp and miRs, and suggests that both P‐ gp and miR may be found in microvesicles or exosomes and may be transported to neighboring, drug‐sensitive cells.