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Hilde Nilsen

Researcher at Akershus University Hospital

Publications -  111
Citations -  12122

Hilde Nilsen is an academic researcher from Akershus University Hospital. The author has contributed to research in topics: DNA glycosylase & DNA repair. The author has an hindex of 33, co-authored 83 publications receiving 10280 citations. Previous affiliations of Hilde Nilsen include University of Oslo & Norwegian University of Science and Technology.

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Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
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Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer’s disease

Evandro Fei Fang, +21 more
- 11 Feb 2019 - 
TL;DR: Evidence that mitophagy is impaired in the hippocampus of AD patients, in induced pluripotent stem cell-derived human AD neurons, and in animal AD models is provided, suggesting that impaired removal of defective mitochondria is a pivotal event in AD pathogenesis and thatMitophagy represents a potential therapeutic intervention.
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Immunoglobulin Isotype Switching Is Inhibited and Somatic Hypermutation Perturbed in UNG-Deficient Mice

Cristina Rada, +5 more
- 15 Oct 2002 - 
TL;DR: The results provide strong support for the DNA deamination model for antibody diversification with respect to class-switching as well as hypermutation and suggest that UNG is the major mouse DNA glycosylase responsible for processing the programmed dU/dG lesions within the immunoglobulin locus.
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Defective Mitophagy in XPA via PARP-1 Hyperactivation and NAD+/SIRT1 Reduction

Evandro Fei Fang, +9 more
- 08 May 2014 - 
TL;DR: This work identifies mitochondrial dysfunction in xeroderma pigmentosum group A (XPA), a nucleotide excision DNA repair disorder with severe neurodegeneration, in silico and in vivo and reveals a nuclear-mitochondrial crosstalk that is critical for the maintenance of mitochondrial health.
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Base excision repair of DNA in mammalian cells

Hans E. Krokan, +4 more
- 30 Jun 2000 - 
TL;DR: Base excision repair of DNA corrects a number of spontaneous and environmentally induced genotoxic or miscoding base lesions in a process initiated by DNA glycosylases.