Lorena Esteban-Martínez

TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: It is shown that embryogenesis‐associated mouse RGC differentiation depends on mitophagy, the programmed autophagic clearance of mitochondria, which contributes to cellular differentiation in several distinct developmental contexts.

TL;DR: It is shown here that survival during mitotic arrest is affected by the special energetic requirements of mitotic cells, which results in mitophagy-dependent loss of mitochondria, accompanied by reduced ATP levels and the activation of AMPK.

TL;DR: The role of autophagy in retinal development and cell differentiation is described, and the implications of Autophagy dysregulation both in physiological aging and in important diseases such as age-associated macular degeneration and glaucoma are discussed.

TL;DR: This work describes a flow cytometry-based approach to determine mitophagy by using MitoTracker Deep Red, a widely used mitochondria-selective probe used in combination with selective inhibitors, and test the validity of the use of this method in cell lines and in primary cell and tissue cultures.