Michael Klinkenberg

TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: There is a Drp1- and Fis1-induced, and PINK1-mediated protection mechanism in senescent cells, which, when compromised, could contribute to the age-related progression of Parkinson's disease and arteriosclerosis.

TL;DR: It is shown that Parkinson's disease-associated genes PINK1 and Parkin direct localized translation of certain nuclear-encoded RCC (nRCC) mRNAs are localized in a Pink1/Tom20-dependent manner to mitochondrial outer membrane, where they are derepressed and activated by Pinks1/Parkin through displacement of translation repressors.

TL;DR: A first characterization of CLPP null mice demonstrated complete female and male infertility and auditory deficits and showed resistance to ulcerative dermatitis, indicating that murine Clpp deletion represents a faithful Perrault model.

TL;DR: Primary skin fibroblasts are a useful Parkinson's disease model, able to serve as a complement to animal mutants, transformed cell lines and patient tissues.