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John W. Steele

Researcher at University of California, San Diego

Publications -  9
Citations -  5391

John W. Steele is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Internal medicine & Medicine. The author has an hindex of 6, co-authored 7 publications receiving 4940 citations. Previous affiliations of John W. Steele include Icahn School of Medicine at Mount Sinai.

Papers
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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
Journal Article

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2459 more
- 01 Jan 2016 - 
Journal ArticleDOI

Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356

Daniel J. Klionsky, +2522 more
- 01 Jan 2016 - 
TL;DR: Author(s): Klionsky, DJ; Abdelmohsen, K; Abe, A; Abedin, MJ; Abeliovich, H; A Frozena, AA; Adachi, H, Adeli, K, Adhihetty, PJ; Adler, SG; Agam, G; Agarwal, R; Aghi, MK; Agnello, M; Agostinis, P; Aguilar, PV; Aguirre-Ghis
Journal ArticleDOI

Effective anti-Alzheimer Aβ therapy involves depletion of specific Aβ oligomer subtypes

Elysse M. Knight, +16 more
- 01 Jun 2016 - 
TL;DR: Evidence is provided that N U4-type soAβ (NU4-soAβ) assemblies accumulate in the brains of Dutch APP E693Q mice and are associated with defects in memory, even in the absence of insoluble Aβ plaques, suggesting targeting of specific soA β assembly subtypes may be an important consideration in the therapeutic and/or prophylactic benefit of anti-Aβ antibody drugs.
Journal ArticleDOI

Evidence that small molecule enhancement of β-hexosaminidase activity corrects the behavioral phenotype in Dutch APP E693Q mice through reduction of ganglioside-bound Aβ

Elysse M. Knight, +14 more
- 01 Feb 2015 - 
TL;DR: Treating Dutch APPE693Q mice with OT1001 was associated with reduced anxiety, improved learning behavior in the NOR task and dramatically reduced GAβ accumulation in the subiculum and perirhinal cortex, both of which are brain regions required for normal NOR.