James Murray

TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: The data suggest that hVps34 is a nutrient-regulated lipid kinase that integrates amino acid and glucose inputs to mTOR and S6K1 and is a critical component of the nutrient sensing apparatus.

TL;DR: NDRG1 and NDRG2 are identified as physiological substrates for SGK1, and it is demonstrated that phosphorylation of N DRG1 by SGK 1 primes it for phosphorylated by GSK3.

TL;DR: It is found that both endogenous hVps34 and p150 are targeted to enlarged endosomal structures in cells expressing constitutively activated Rab5, where they are significantly colocalized with EEA1.

TL;DR: It is demonstrated that ULK 1 is required for autophagy in severe hypoxia and that ablation of ULK1 causes caspase-3/7-independent cell death, and suggested as a potentially effective target for cancer therapy.