Pei-Yu Wang

TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: It is concluded that Indy and CR interact to affect longevity and that a decrease in Indy may induce a CR-like status that confers life span extension.

TL;DR: It is found that motor neurons from adult mice synthesize MIS and express its receptors, suggesting that mature motor neurons use MIS in an autocrine fashion or as a way to communicate with each other.

TL;DR: A signature enrichment analysis of metabolic and signaling pathways revealed that expression levels of genes in the oxidative phosphorylation pathway are significantly lower in Indy starting at day 20, indicating one potential mechanism by which Indy mutants extend life span through an alteration in mitochondrial physiology leading to an increased efficiency in the ATP/ROS ratio.