Monica Hagedorn

TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: Using the social amoeba Dictyostelium as a genetically tractable host for pathogenic mycobacteria, it is discovered that M. tuberculosis and M. marinum, but not M. avium, are ejected from the cell through an actin-based structure, the ejectosome, and this conserved nonlytic spreading mechanism requires a cytoskeleton regulator from the host and an intactMycobacterial ESX-1 secretion system.

TL;DR: WASH coats mature lysosomes and is required for exocytosis of indigestible material.

TL;DR: It is found that two host proteins – the flotillin homologue vacuolin and p80, a predicted copper transporter – accumulate at the vacuole during pathogen replication until it finally ruptures and the bacteria are released into the host cytosol.

TL;DR: A systematic analysis addressing how macrophages kill ‘non‐pathogenic’ Mycobacterium smegmatis found that map kinase p38 is a crucial regulator of all processes investigated, except NO synthesis, that facilitated the host for some functions while being usurped by live bacteria for others.