Jian Xu

TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: The results suggest adipocyte Metrnl controls insulin sensitivity at least via its local autocrine/paracrine action through the PPARγ pathway, and may become a therapeutic target for insulin resistance.

TL;DR: It is found that Curcumin treatment enhances autophagic flux in both human colon cancer HCT116 cells and mouse embryonic fibroblasts, and transcription factor EB (TFEB) is activated, providing a novel insight into the regulatory mechanisms ofCurcumin on autophagy and lysosome, which may facilitate the development of curcumin as a potential cancer therapeutic agent.

TL;DR: Author(s): Klionsky, DJ; Abdelmohsen, K; Abe, A; Abedin, MJ; Abeliovich, H; A Frozena, AA; Adachi, H, Adeli, K, Adhihetty, PJ; Adler, SG; Agam, G; Agarwal, R; Aghi, MK; Agnello, M; Agostinis, P; Aguilar, PV; Aguirre-Ghis

TL;DR: Evidence that inhibition of autophagy would serve as a novel strategy for enhancing the anti-cancer potential of physapubescin B is provided, indicating thatAutophagy serves as a cell survival mechanism to protect cell death.