Sang Won Suh

TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: A novel glycogen phosphorylase inhibitor is used, CP-316,819, that causes glycogen accumulation under normoglycemic conditions but permits glycogen utilization when glucose concentrations are low, to establish a novel approach for manipulating brain glycogen concentration in normal, awake animals and provide in vivo confirmation that astrocyte glycogen supports neuronal function and survival during glucose deprivation.

TL;DR: The present study indicates that apocynin pre-treatment prevents TBI-induced ROS production, thus decreasing BBB disruption, neuronal death and microglial activation, and suggests that inhibition of NADPH oxidase by apoynin may have a high therapeutic potential to reduce traumatic brain injury-induced neuronal death.

TL;DR: Results suggest that zinc translocation is an intermediary step linking hypoglycemia to PARP-1 activation and neuronal death.

TL;DR: Administration of PJ34 as late as 8 hours after transient ischemia–reperfusion has a large protective effect on CA1 survival, mediated by suppression of the postischemic brain inflammatory response.