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Stefano Toldo

Researcher at Virginia Commonwealth University

Publications -  142
Citations -  11519

Stefano Toldo is an academic researcher from Virginia Commonwealth University. The author has contributed to research in topics: Inflammasome & Heart failure. The author has an hindex of 39, co-authored 121 publications receiving 9431 citations. Previous affiliations of Stefano Toldo include Catholic University of the Sacred Heart & The Catholic University of America.

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Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
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The inflammasome promotes adverse cardiac remodeling following acute myocardial infarction in the mouse

TL;DR: The presence of the inflammasome in the mouse heart in an experimental mouse model of AMI as evidenced by increased caspase-1 activity and cytoplasmic aggregates of the three components of theInflammasomes may represent a unique therapeutic strategy to limit cell death and prevent heart failure after AMI.
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The NLRP3 inflammasome in acute myocardial infarction.

TL;DR: Evidence supporting the therapeutic value of NLRP3 inflammasome-targeted strategies in experimental models is summarized and the data supporting the role of the NLRP2 inflammaome in AMI and its consequences on adverse cardiac remodelling, cytokine-mediated systolic dysfunction, and heart failure are summarized.
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Interleukin-1 and the Inflammasome as Therapeutic Targets in Cardiovascular Disease

TL;DR: There is overwhelming evidence linking the NLRP3 inflammasome and the IL-1 cytokines with the pathogenetic role of atherosclerosis, in ischemic (acute myocardial infarction), and nonischemic injury to the myocardium (myocarditis) and the progression to heart failure.
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Targeting Interleukin-1 in Heart Disease

TL;DR: Interleukin-1 (IL-1) is an apical proinflammatory mediator in acute and chronic inflammation and a powerful inducer of the innate immune response and this step is key in the pathogenesis of many autoinflammatory diseases.